Endocrine Abstracts

In arthritides, such as osteoarthritis (OA), there is considerable bone and cartilage remodelling associated with the disease progression. The destruction of these tissues is responsible for the pain and disability associated with the disease. Metalloproteinases (MPs) are thought to contribute to this process but as yet this remains unproven in the clinic.The objective of this study was to elucidate the role of the specific MPs, aggrecanase and collagen...